Background

Periungual warts (PW), also known as verruca vulgaris, are caused by the human papillomavirus

and appear as skin lesions located around the nail fold but can also affect the nail plate.

Unfortunately, some of the therapies mentioned are destructive by nature and can also

damage the nail matrix, hyponychium, or underlying bone.

Case description

Here we describe a patient resistant to a range of standard treatments.

His clinical condition dramatically improved after the use of isolated transfer factors (TF).

Conclusion

As shown in this case, TF could be a possible effective alternative

to treat therapy-resistant PW and we hope this report will lead to further investigation,

including controlled trials with TF in this patient group.